Biologic and Nonbiologic Systemic Agents and Phototherapy for Treatment of Chronic Plaque Psoriasis: Comparative Effectiveness Review Number 85 by U. S. Department of Health and Human Services, Agency for Healthcare Research and Quality
Biologic and Nonbiologic Systemic Agents and Phototherapy for Treatment of Chronic Plaque Psoriasis: Comparative Effectiveness Review Number 85 by U. S. Department of Health and Human Services, Agency for Healthcare Research and Quality PDF, ePub eBook D0wnl0ad
Psoriasis is a common, chronic, autoimmune inflammatory skin disease affecting 2 to 3 percent of the worldwide population. The onset of psoriasis predominantly occurs early in adulthood (between the ages of 15 and 25 years) but may affect individuals at any age. The course of psoriasis is marked by chronic and acute phases with a wide variety in relapse and clearance rates. Total health care costs of psoriasis are estimated at $11.25 billion annually. This economic burden, along with the clinically relevant reductions in quality of life experienced by many patients with psoriasis, underscores the need for prompt, effective, and sustained disease management. Among several clinical psoriasis phenotypes, chronic plaque psoriasis is the most frequent, accounting for all but 10 percent of cases. Chronic plaque psoriasis, also known as psoriasis vulgaris, often appears as well-demarcated, erythematous plaques covered with silvery white scales that vary in size up to several centimeters. Different parameters determine disease severity such as the degree of body surface area (BSA) involved, activity of the lesions, the location of lesions in sensitive areas, duration of disease, treatment failures, and the impact on quality of life. While disease localized to nonsensitive areas of skin may be managed effectively with topical agents, patients with more widespread disease often require systemic treatment. The American Academy of Dermatology has published guidelines for the treatment of psoriasis and suggest use of either biologic or nonbiologic systemic agents or phototherapy with ultraviolet B (UVB) or with psoralen plus ultraviolet A (PUVA) therapy in patients with widespread disease. Biologic therapies for psoriasis use genetically engineered drugs that target specific steps in the pathogenesis of psoriasis involving T cells and cytokines . Currently, three biologic TNF-alpha inhibitors (infliximab, etanercept, and adalimumab), and one anti-IL 12/23 agent (ustekinumab) have approval from the Food and Drug Administration (FDA) for psoriasis treatment. Nonbiologic systemic therapies may be effective but can be associated with significant short-term and longterm adverse events (hepatotoxicity, nephrotoxicity, hypertension, dyslipidemia, malignancy, and teratogenicity). Phototherapy, although considered to be one of the safer therapeutic options, requires strict compliance, and the long-term toxicity associated with it includes photocarcinogenesis. The objective of this comparative effectiveness review (CER) is to examine the benefits and harms of biologic systemic agents compared with nonbiologic systemic agents or phototherapy in patients with chronic plaque psoriasis. The Key Questions addressed in this review include: Key Question 1. In patients with chronic plaque psoriasis, what is the comparative effectiveness of systemic biologic agents and systemic nonbiologic agents (between-class comparisons on an individual drug level) or phototherapy when evaluating intermediate (plaque BSA measurement, PASI , Patient’s Assessment of Global Improvement, PGA, and individual symptom improvement) and final health outcomes (mortality, HRQoL and other patient-reported outcomes, MACE, diabetes, and psychological comorbidities )? Key Question 2. In patients with chronic plaque psoriasis, what is the comparative safety of systemic biologic agents and systemic nonbiologic agents (between-class comparisons on an individual drug level) or phototherapy (hepatotoxicity, nephrotoxicity, hematologic toxicity, hypertension, alteration in metabolic parameters, injection site reaction, malignancy, infection, and study withdrawal)? Key Question 3. In patients with chronic plaque psoriasis treated with systemic biologic therapy, systemic nonbiologic therapy, or phototherapy, which patient or disease characteristics affect intermediate and final outcomes?From reader reviews:
Donna Cook:
This Biologic and Nonbiologic Systemic Agents and Phototherapy for Treatment of Chronic Plaque Psoriasis: Comparative Effectiveness Review Number 85 is great reserve for you because the content which is full of information for you who else always deal with world and have to make decision every minute. This specific book reveal it data accurately using great coordinate word or we can say no rambling sentences inside. So if you are read the item hurriedly you can have whole information in it. Doesn't mean it only gives you straight forward sentences but hard core information with wonderful delivering sentences. Having Biologic and Nonbiologic Systemic Agents and Phototherapy for Treatment of Chronic Plaque Psoriasis: Comparative Effectiveness Review Number 85 in your hand like obtaining the world in your arm, data in it is not ridiculous 1. We can say that no publication that offer you world with ten or fifteen second right but this book already do that. So , this is good reading book. Hi Mr. and Mrs. occupied do you still doubt this?
Elvira Eberhardt:
Reading a book for being new life style in this season; every people loves to read a book. When you examine a book you can get a lots of benefit. When you read ebooks, you can improve your knowledge, due to the fact book has a lot of information into it. The information that you will get depend on what sorts of book that you have read. If you want to get information about your examine, you can read education books, but if you act like you want to entertain yourself you are able to a fiction books, such us novel, comics, along with soon. The Biologic and Nonbiologic Systemic Agents and Phototherapy for Treatment of Chronic Plaque Psoriasis: Comparative Effectiveness Review Number 85 will give you a new experience in looking at a book.
Charles Moreno:
Beside this Biologic and Nonbiologic Systemic Agents and Phototherapy for Treatment of Chronic Plaque Psoriasis: Comparative Effectiveness Review Number 85 in your phone, it can give you a way to get closer to the new knowledge or facts. The information and the knowledge you can got here is fresh in the oven so don't always be worry if you feel like an previous people live in narrow commune. It is good thing to have Biologic and Nonbiologic Systemic Agents and Phototherapy for Treatment of Chronic Plaque Psoriasis: Comparative Effectiveness Review Number 85 because this book offers to you personally readable information. Do you oftentimes have book but you rarely get what it's interesting features of. Oh come on, that would not happen if you have this in the hand. The Enjoyable set up here cannot be questionable, just like treasuring beautiful island. Techniques you still want to miss this? Find this book in addition to read it from today!
Read Biologic and Nonbiologic Systemic Agents and Phototherapy for Treatment of Chronic Plaque Psoriasis: Comparative Effectiveness Review Number 85 by U. S. Department of Health and Human Services, Agency for Healthcare Research and Quality for online ebook
Biologic and Nonbiologic Systemic Agents and Phototherapy for Treatment of Chronic Plaque Psoriasis: Comparative Effectiveness Review Number 85 by U. S. Department of Health and Human Services, Agency for Healthcare Research and Quality Free PDF d0wnl0ad, audio books, books to read, good books to read, cheap books, good books, online books, books online, book reviews epub, read books online, books to read online, online library, greatbooks to read, PDF best books to read, top books to read Biologic and Nonbiologic Systemic Agents and Phototherapy for Treatment of Chronic Plaque Psoriasis: Comparative Effectiveness Review Number 85 by U. S. Department of Health and Human Services, Agency for Healthcare Research and Quality books to read online.
Tidak ada komentar:
Posting Komentar